PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.5 (21 Mar 2021): Spring of Hope! (Release History)

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1H nuclear magnetic resonance spectroscopy-based studies of the metabolism of food-borne carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline by human intestinal microbiota. 16151094 2005 Research
A Two-Way Interaction between Methotrexate and the Gut Microbiota of Male Sprague-Dawley Ratsز 32544340 2020 Research
Acetamide--a metabolite of metronidazole formed by the intestinal flora 231450 1979 Research
Akkermansia Muciniphila Potentiates the Antitumor Efficacy of FOLFOX in Colon Cancer. 34603035 2021 Research
Alterations in the intestinal glycocalyx and bacterial flora in response to oral indomethacin. 15979923 2005 Research
Ammonia and glutamine metabolism of the intestine. The effect of lactulose and neomycin. 3759231 1986 Research
Anaerobic C-ring cleavage of genistein and daidzein by Eubacterium ramulus. 11959436 2002 Research
Anaerobic metabolism of 1-amino-2-naphthol-based azo dyes (Sudan dyes) by human intestinal microflora. 17933925 2007 Research
Anti-inflammatory properties of a pomegranate extract and its metabolite urolithin-A in a colitis rat model and the effect of colon inflammation on phenolic metabolism. 19616930 2009 Research
Antipsychotics and the gut microbiome: olanzapine-induced metabolic dysfunction is attenuated by antibiotic administration in the ratز 24084940 2013 Research
Arsenic metabolism by human gut microbiota upon in vitro digestion of contaminated soils. 20603239 2010 Research
Aspirin Modulation of the Colorectal Cancer-Associated Microbe Fusobacterium nucleatum. 33824205 2021 Research
Association Between the Prothrombin Time-International Normalized Ratio and Concomitant Use of Antibiotics in Warfarin Users: Focus on Type of Antibiotic and Susceptibility of Bacteroides fragilis to Antibioticsز 32633584 2021 Research
Bacterial acetylation of 5-aminosalicylic acid in faecal suspensions cultured under aerobic and anaerobic conditions 1425876 1992 Research
Bacteroides uniformis is a putative bacterial species associated with the degradation of the isoflavone genistein in human feces. 21525249 2011 Research
Baicalin, the predominant flavone glucuronide of scutellariae radix, is absorbed from the rat gastrointestinal tract as the aglycone and restored to its original form. 11197087 2000 Research
Berberine combined with stachyose improves glycometabolism and gut microbiota through regulating colonic microRNA and gene expression in diabetic rats. 34480937 2021 Research
Berberine combined with stachyose induces better glycometabolism than berberine alone through modulating gut microbiota and fecal metabolomics in diabetic mice. 31833107 2020 Research
Bidirectional interactions between curcumin and gut microbiota in transgenic mice with Alzheimer’s disease. 32095862 2020 Research
Biodegradability of fluoxetine, mefenamic acid, and metoprolol using different microbial consortiums. 28091995 2017 Research
Chlorogenic acid bioavailability largely depends on its metabolism by the gut microflora in rats. 12771329 2003 Research
Ciprofloxacin decreases the rate of ethanol elimination in humans. 10026319 1999 Research
Colonic metabolism of ranitidine: implications for its delivery and absorption 11564550 2001 Research
Compositional variation of the human fecal microbiome in relation to azo-reducing activity: a pilot study. 34625106 2021 Research
Degradation of insulin and calcitonin and their protection by various protease inhibitors in rat caecal contents: implications in peptide delivery to the colon. 9055189 1997 Research
Dietary selenium affects host selenoproteome expression by influencing the gut microbiota. 21493887 2011 Research
Dietary Serine-Microbiota Interaction Enhances Chemotherapeutic Toxicity Without Altering Drug Conversion. 32444616 2020 Research
Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine. 25263219 2014 Research
Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism. 31196984 2019 Research
Drinking Hydrogen-Rich Water Alleviates Chemotherapy-Induced Neuropathic Pain Through the Regulation of Gut Microbiota. 33732014 2021 Research
Effect of Bifidobacterium on olanzapine-induced body weight and appetite changes in patients with psychosis. 34002246 2021 Research
Effect of Hesperidin on Cardiovascular Disease Risk Factors: The Role of Intestinal Microbiota on Hesperidin Bioavailability. 32443766 2020 Review
Effects of cyadox and olaquindox on intestinal mucosal immunity and on fecal shedding of Escherichia coli in piglets. 16908639 2006 Research
Effects of dietary fiber intake in chemotherapy-induced mucositis in murine model. 33298215 2020 Research
Effects of dietary fibre-rich juice colloids from apple pomace extraction juices on intestinal fermentation products and microbiota in rats. 13129467 2003 Research
Effects of intestinal microbiota on the bioavailability of geniposide in rats. 25257195 2014 Research
Effects of lactitol on intestinal microflora and plasma endotoxin in patients with chronic viral hepatitis. 17049992 2006 Research
Effects of orally administered antibiotics on the bioavailability of amlodipine: gut microbiota-mediated drug interaction. 26630218 2016 Research
Encapsulation and micronization effectively improve orange beverage flavanone bioavailability in humans. 25200135 2014 Research
Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis. 24192039 2013 Research
Formation of catechol estrogens by intestinal bacterial demethylation of 2-methoxyestrone 6299367 1983 Research
Fusobacterium nucleatum Promotes Chemoresistance to Colorectal Cancer by Modulating Autophagy. 28753429 2017 Research
Genetic and chemical characterization of ibuprofen degradation by Sphingomonas Ibu-2 23329679 2013 Research
Geographic differences in digoxin inactivation, a metabolic activity of the human anaerobic gut flora. 2759492 1989 Research
Ginsenoside metabolites, rather than naturally occurring ginsenosides, lead to inhibition of human cytochrome P450 enzymes. 16547074 2006 Research
Gut bacterial tyrosine decarboxylases restrict levels of levodopa in the treatment of Parkinson’s disease. 30659181 2019 Research
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. 21475195 2011 Research
Gut microbiome affects the metabolism of metronidazole in mice through regulation of hepatic cytochromes P450 expression. 34752478 2021 Research
Gut microbiome composition can predict the response to nivolumab in advanced hepatocellular carcinoma patients. 34876793 2021 Research
Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study). 33024120 2020 Research
Gut microbiota is critical for the induction of chemotherapy-induced pain. 28714953 2017 Research
Gut microbiota-mediated drug interactions between lovastatin and antibiotics. 24947972 2014 Research
Gut Microbiota-Mediated Drug-Drug Interaction between Amoxicillin and Aspirin. 31700098 2019 Research
Gut microflora interactions with xylitol in the mouse, rat and man. 4076932 1985 Research
Impact of the Gut Microbiota on Atorvastatin Mediated Effects on Blood Lipids. 32466086 2020 Research
Induction and Amelioration of Methotrexate-Induced Gastrointestinal Toxicity are Related to Immune Response and Gut Microbiotaز 30049384 2018 Research
Inhibition effects of eight anti-coronavirus drugs on glycosides metabolism and glycosidases in human gut microflora. 33964992 2021 Research
Intestinal anaerobic bacteria hydrolyse sorivudine, producing the high blood concentration of 5-(E)-(2-bromovinyl)uracil that increases the level and toxicity of 5-fluorouracil. 9110360 1997 Research
Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. 23563705 2013 Research
Investigations of hydrazine cleavage of eltrombopag in humans. 21646438 2011 Research
Involvement of β-glucuronidase in intestinal microflora in the intestinal toxicity of the antitumor Camptothecin derivative Irinotecan Hydrochloride (CPT-11) in rats 8706020 1996 Research
Lactobacillus reuteri Alleviates Gastrointestinal Toxicity of Rituximab by Regulating the Proinflammatory T Cells in vivo. 34712207 2021 Research
m-Hydroxyphenylacetic acid formation from L-dopa in man: suppression by neomycin. 5350345 1969 Research
Mechanism of cholesterol reduction to coprostanol by Eubacterium coprostanoligenes ATCC 51222. 8789734 1996 Research
Mechanistic elucidation of amphetamine metabolism by tyramine oxidase from human gut microbiota using molecular dynamics simulations. 30701587 2019 Research
Melamine-induced renal toxicity is mediated by the gut microbiota. 23408055 2013 Research
Metabolic conversion of indicine N-oxide to indicine in rabbits and humans. 476682 1979 Research
Metabolic fate of a new histamine H2-receptor antagonist, Z-300, in rat. 10553721 1999 Research
Metabolism of azo dyes by human skin microbiota. 19729456 2010 Research
Metabolism of cyadox by the intestinal mucosa microsomes and gut flora of swine, and identification of metabolites by high-performance liquid chromatography combined with ion trap/time-of-flight mass spectrometry 21766376 2011 Research
Metabolism of daidzein by fecal bacteria in rats. 17605343 2007 Research
Metabolism of digoxin and absorption site. 7104181 1982 Research
Metabolism of levamisole, an anti-colon cancer drug, by human intestinal bacteria. 1949905 1991 Research
Metabolism of N-acylated and O-alkylated drugs by the intestinal microflora during anaerobic incubation in vitro 4418213 1974 Research
Metabolism of omeprazole by gut flora in rats. 7629748 1995 Research
Metabolism of rutin and poncirin by human intestinal microbiota and cloning of their metabolizing α-L-rhamnosidase from Bifidobacterium dentium. 25179902 2015 Research
Metabolism, microflora effects, and genotoxicity in haloacetic acid-treated cultures of rat cecal microbiota. 11248134 2001 Research
Methotrexate impacts conserved pathways in diverse human gut bacteria leading to decreased host immune activation. 33440172 2021 Research
Microbial hydrolysis of steviol glycosides. 18550247 2008 Research
Microbial Unmasking of Plant Glycosides. 29382739 2018 Research
Microbiome-derived inosine modulates response to checkpoint inhibitor immunotherapy. 32792462 2020 Research
Modulating gut microbiota as an anti-diabetic mechanism of berberine 21709646 2011 Research
Mycoplasma hyorhinis-encoded cytidine deaminase efficiently inactivates cytosine-based anticancer drugs. 26322268 2015 Research
Nectar xylose metabolism in a rodent pollinator (Aethomys namaquensis): defining the role of gastrointestinal microflora using 14C-labeled xylose. 16380937 2005 Research
Novel approaches for analysing gut microbes and dietary polyphenols: challenges and opportunities. 20724384 2010 Research
Novel gut-based pharmacology of metformin in patients with type 2 diabetes mellitus. 24988476 2014 Research
Nuciferine modulates the gut microbiota and prevents obesity in high-fat diet-fed rats 33262480 2020 Research
Omeprazole induces altered bile acid metabolism. 9536953 1998 Research
On the colonic bacterial metabolism of azo-bonded prodrugsof 5-aminosalicylic acidز 25091594 2014 Research
Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism. 19667173 2009 Research
Predicting and manipulating cardiac drug inactivation by the human gut bacterium Eggerthella lenta. 23869020 2013 Research
Prevotella copri is associated with carboplatin-induced gut toxicity 31558709 2019 Research
Prophylactic Treatment with Vitamins C and B2 for Methotrexate-Induced Gastrointestinal Mucositis. 33383956 2020 Research
Quantitative modeling predicts mechanistic links between pre-treatment microbiome composition and metronidazole efficacy in bacterial vaginosis. 33262350 2020 Research
Reduction of nitrazepam by Clostridium leptum, a nitroreductase-producing bacterium isolated from the human intestinal tract 9310649 1997 Research
Reduction of the prodrug loperamide oxide to its active drug loperamide in the gut of rats, dogs, and humans. 7628301 1995 Research
Resveratrol-mediated attenuation of superantigen-driven acute respiratory distress syndrome is mediated by microbiota in the lungs and gut. 33722710 2021 Research
Role of gut flora on intestinal group II phospholipase A2 activity and intestinal injury in shock. 11557516 2001 Research
Role of intestinal bacteria in gliadin-induced changes in intestinal mucosa: study in germ-free rats. 21249146 2011 Research
Role of intestinal microorganisms in determining cycasin toxicity. 4960684 1967 Research
Role of the gastrointestinal microflora in amygdalin (laetrile)-induced cyanide toxicity. 7362642 1980 Research
Role of the intestinal flora in the metabolism of misonidazole. 6260109 1980 Research
Role of the intestinal microflora in clonazepam metabolism in the rat. 6506755 1984 Research
Six-Week Consumption of a Wild Blueberry Powder Drink Increases Bifidobacteria in the Human Gut 22060186 2011 Research
Splenda alters gut microflora and increases intestinal p-glycoprotein and cytochrome p-450 in male rats. 18800291 2008 Research
Studies of the metabolism of methotrexate by intestinal flora. I. Identification and study of biological properties of the metabolite 4-amino-4-deoxy-N 10 -methylpteroic acid. 5014749 1972 Research
Susceptibility of the H2-receptor antagonists cimetidine, famotidine and nizatidine, to metabolism by the gastrointestinal microflora. 11955801 2002 Research
Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4. 25065623 2014 Research
The Ameliorative Effects of Isorhynchophylline on Morphine Dependence Are Mediated Through the Microbiota-Gut-Brain Axis. 34168553 2021 Research
The antipsychotic olanzapine interacts with the gut microbiome to cause weight gain in mouse. 25506936 2014 Research
The Diversity of Gut Microbiome is Associated With Favorable Responses to Anti-Programmed Death 1 Immunotherapy in Chinese Patients With NSCLC. 31026576 2019 Research
The effect of gut microbiota on drug metabolism 24033282 2013 Review
The effect of low-pressure carbonation on the heat inactivation of Escherichia coli. 21979074 2011 Research
The ellagic acid-derived gut microbiota metabolite, urolithin A, potentiates the anticancer effects of 5-fluorouracil chemotherapy on human colon cancer cells.. 25857357 2015 Research
The Gut Microbiome Associates with Immune Checkpoint Inhibition Outcomes in Patients with Advanced Non-Small Cell Lung Cancer. 32847937 2020 Research
The gut microbiome influences the bioavailability of olanzapine in rats. 33819741 2021 Research
The gut microbiota mediates the protective effects of anserine supplementation on hyperuricaemia and associated renal inflammation. 34382991 2021 Research
The human colonic microflora influences the alterations of xenobiotic-metabolizing enzymes by catechins in male F344 rats 12659723 2003 Research
The impact of intestinal microflora on serum bilirubin levels. 15664250 2005 Research
The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide. 24264990 2013 Research
The Pre-treatment Gut Microbiome is Associated with Lack of Response to Methotrexate in New Onset Rheumatoid Arthritis. 33314800 2020 Research
The reduction of sulphinpyrazone and sulindac by intestinal bacteria. 3630204 1987 Research
The role of enteric bacteria in the pathogenesis of fatal cycloheximide intolerance in mice pretreated with dexamethasone, promethazine or nordihydroguaiaretic acid. 8841837 1996 Research
The role of gut microbiota in the pharmacokinetics of antihypertensive drugs. 29391236 2018 Research
The role of mammalian intestinal bacteria in the reductive metabolism of zonisamide 9231340 1997 Research
The role of the gut flora in the metabolism of cyclamate. 4655823 1972 Research
The role of the gut flora in the metabolism of prontosil and neoprontosil in the rat. 5173017 1971 Research
Tissue content of mercury in rats given methylmercuric chloride orally: influence of intestinal flora. 7387196 1980 Research
Transforming berberine into its intestine-absorbable form by the gut microbiota. 26174047 2015 Research
Urinary excretion of reduced metabolites of digoxin. 7246583 1981 Research
Vaginal bacteria modify HIV tenofovir microbicide efficacy in African women. 28572388 2017 Research