The PharmacoMicrobiomics web portal is a part of an initiative to explore the interactions between human-associated microbes (human microbiome) and drugs by building a knowledgebase that allows interested students and investigators "to predict the behavior of untested members of drug classes or unstudied microbial species, and to design laboratory experiments for testing these predictions. (More in BMC Bioinformatics 2011, 12(Suppl 7):A10)
What to Find Here?
You will be able to find different types of information mostly related to the effect of microbes on drugs (more specifically on the effect of human microbiota on drug disposition or pharmacokinetics). In the future, there may be more information about more complex drug-microbe interactions, and about microbes as drugs, drug factories, or drug-delivery vehicles.
You now can find several entries in the database, including:
- a list of drugs with entries in the database
- the actual list of all body site-drug-microbe interactions
- a list of references to publications describing body site-drug-microbe interactions. Many of those publications have been already curated in the "relations" table, but some of them are not.
You can also find more entries still in "draft" format (mostly Google Docs) that describe a long reading/task list for our current or future curators, and also for those community volunteers who are willing to join our efforts.
|chlorogenic acid (1794427)|
|affect metabolic processing|
|Gut microbiota metabolize chlorogenic acid in to 3- hydroxy cinnamic acid and 3-(hydroxyl phenyl) propionic acid which are subject to phase II conjugation followed by excretion in urine. In absence of gut microbiota, chlorogenic acid is metabolized to benzoic acid which in turn is conjugated with glycine yielding hippuric acid. This has been verified by the absence of these metabolites upon administration of antibiotics and in germ free rats. Gonthier et al reported that the bioavailability of chlorogenic relies on its metabolism by gut microbiota. Variation in the concentrations of chlorogenic acid metabolites was found among rat population. H1NMR spectroscopy showed that elevated concentration of the metabolites in urine was accompanied by low hippuric acid concentration in a rat subpopulation that is similar in terms of species, genetic background and conditions of maintenance to the other group of rats (Gavaghan et al, 2001). This suggests the difference in gut microbiota between the two rats populations. Based on the results retrieved by Gonthier et al, the elevated concentration of the metabolites will result in turn in increased bioavailability and thereby augmented efficacy. (See record)|
This drug-microbiome database was designed and built as the graduation project of the Open Source Technologies track at the Information Technology Institute (ITI) in June, 2011.
Django, the Python-based framework, was used to build the web portal, and JQuery libraries. JLinkPreview plugin is provided by Sarpdoruk Tahmaz. This template is distributed under a Creative Commons Attribution 2.5 License by Arcsin Web Templates. The project is hosted by WebFaction.