PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.5 (21 Mar 2021): Spring of Hope! (Release History)

Welcome To PharmacoMicrobiomics!

The PharmacoMicrobiomics web portal is a part of an initiative to explore the interactions between human-associated microbes (human microbiome) and drugs by building a knowledgebase that allows interested students and investigators "to predict the behavior of untested members of drug classes or unstudied microbial species, and to design laboratory experiments for testing these predictions. (More in BMC Bioinformatics 2011, 12(Suppl 7):A10)



What to Find Here?

You will be able to find different types of information mostly related to the effect of microbes on drugs (more specifically on the effect of human microbiota on drug disposition or pharmacokinetics). In the future, there may be more information about more complex drug-microbe interactions, and about microbes as drugs, drug factories, or drug-delivery vehicles.


You now can find several entries in the database, including:

You can also find more entries still in "draft" format (mostly Google Docs) that describe a long reading/task list for our current or future curators, and also for those community volunteers who are willing to join our efforts.


Random Interaction

Gut
Olanzapine (135398745)
Bacteria (2)
24084940
(Year: 2013)
increase N/A
Olanzapine, an atypical antipsychotic drug, causes a known side effect of increased body weight and visceral fat in many previous reports. The gut microbiota plays a non-negligible role in augmenting this side effect. This study shows a difference in the gut microbiota in rats after treatment with olanzapine alone or olanzapine-antibiotics. The rapid weight gain is lower significantly in olanzapine-antibiotics treated groups(P<0.05) and lower uterine fat (P<0.05) compared with olanzapine alone. These effects can be owing to dysbiosis of the gut microbiome. Increasing in the abundance of Firmicutes and reduction of Bacteriodetes were observed in the olanzapine treated group alone. In contrast to the olanzapine-antibiotics group, a reduction in Firmicutes and an increase in Bacteriodetes were observed. (See record)


Credits

This drug-microbiome database was designed and built as the graduation project of the Open Source Technologies track at the Information Technology Institute (ITI) in June, 2011.

Django, the Python-based framework, was used to build the web portal, and JQuery libraries. JLinkPreview plugin is provided by Sarpdoruk Tahmaz. This template is distributed under a Creative Commons Attribution 2.5 License by Arcsin Web Templates. The project was hosted by WebFaction (2011-2021). It is currently hosted by Digital Ocean.