| 78 | |
| Summary | Urogenital tract microbes (species: Gardnerella vaginalis) increase tenofovir's metabolic processing. |
| Urogenital tract | |
| tenofovir (PubChem CID: 464205) | |
| Gardnerella vaginalis (Tax ID: 2702) | |
| 28572388 | |
| increase metabolic processing | |
| The vaginal microbiota significantly modulated the microbicide efficacy of tenofovir gel. Specifically, in women with a Lactobacillus-dominated vaginal microbiota, tenofovir effectively reduced HIV incidence by 61%. However, in women whose vaginal microbiota was dominated by Gardenerella vaginalis and other anaerobes, the drug was more or less ineffective (a non-significant incidence reduction of 18%, with p-value = 0.644). In the latter group (non-Lactobacillus group), detectible mucosal tenofovir levels were lower. Thus, Gardnerella vaginalis and other anaerobes are believed to have depleted tenofovir by metabolism. |
Browse Drug-Microbiome Relationship
Home