PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.5 (21 Mar 2021): Spring of Hope! (Release History)

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Summary Urogenital tract microbes (species: Gardnerella vaginalis) increase tenofovir's metabolic processing.
Urogenital tract
tenofovir (PubChem CID: 464205)
Gardnerella vaginalis (Tax ID: 2702)
increase metabolic processing
The vaginal microbiota significantly modulated the microbicide efficacy of tenofovir gel. Specifically, in women with a Lactobacillus-dominated vaginal microbiota, tenofovir effectively reduced HIV incidence by 61%. However, in women whose vaginal microbiota was dominated by Gardenerella vaginalis and other anaerobes, the drug was more or less ineffective (a non-significant incidence reduction of 18%, with p-value = 0.644). In the latter group (non-Lactobacillus group), detectible mucosal tenofovir levels were lower. Thus, Gardnerella vaginalis and other anaerobes are believed to have depleted tenofovir by metabolism.

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