PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.5 (21 Mar 2021): Spring of Hope! (Release History)

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Summary Gut microbes (species: Prevotella copri) increase Carboplatin's toxicity.
Carboplatin (PubChem CID: 426756)
Prevotella copri (Tax ID: 165179)
increase toxicity
Carboplatin is a widely used anticancer drug, and, like most chemotherapeutic agents, it causes mucositis, diarrhea, bloating, and weight loss in almost all patients. These side effects are not only systemic but also local. Carboplatin increases the abundance of Prevotella copri in the gut, which is positively correlated with intestinal mucositis.

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