PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.3 (21 March 15)

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Summary Gut microbes (species: Prevotella copri) increase Nivolumab's response to substance.
Gut
Nivolumab (PubChem CID: 381129577)
Prevotella copri (Tax ID: 165179)
31026576
increase response to substance
patient with Non-small-cell lung carcinoma receiving nivolumab (anti–PD-1) with great diversity of gut microbiome (Alistipes putredinis, Bifidobacterium longum, and Prevotella copri) show response to this drug by showing high frequency of specific memory CD8+ T cell and natural killer cell subset in the periphery.

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