PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.3 (21 March 15)

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Summary Gut microbes (currently unknown members) increase Aspirin's toxicity.
Gut
Aspirin (PubChem CID: 2244)
unknown
31700098
increase toxicity
drug-drug interaction between Aspirin and Amoxicillin. it's sought that aspirin were metabolized by gut microbes to produce salicylic acid. and co-administration with amoxicillin (which reduce the diversity and abundance of gut microbes as Helicobacter pylori and Prevotella_copri) slow down the metabolism of aspirin and increase it's toxicity.

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