| 102 | |
| Summary | Gut microbes (currently unknown members) decrease Aspirin's toxicity. |
| Gut | |
| Aspirin (PubChem CID: 2244) | |
| unknown | |
| 31700098 | |
| decrease toxicity | |
| The interaction between aspirin and amoxicillin is driven by the microbiota. The gut microbiota converts aspirin to the active metabolite salicylic acid. Co-administration of aspirin with amoxicillin (which reduces the diversity and abundance of gut microbes, e.g., Helicobacter pylori and Prevotella_copri) slows down this metabolism, resulting in decreasing aspirin activity and increasing side effects. |
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