PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.5 (21 Mar 2021): Spring of Hope! (Release History)

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Summary Gut microbes (species: Escherichia coli) increase Amphetamine's activity.
Gut
Amphetamine (PubChem CID: 3007)
Escherichia coli (Tax ID: 562)
30701587
increase activity
The central nervous system stimulant, amphetamine, can be metabolized by tyrosine oxidase expressed by E. coli. This metabolism increases the bioavailability of amphetamine, and therefore its efficacy.

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