PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.5 (21 Mar 2021): Spring of Hope! (Release History)

Detailed View

Summary Gut microbes (species: Escherichia coli) increase 5-Fluorouracil's toxicity.
5-Fluorouracil (PubChem CID: 3385)
Escherichia coli (Tax ID: 562)
increase toxicity
A diet containing thymidine and serine could increase the toxicity of the chemotherapeutic agent, 5-Fluorouracil(5FU), via two different mechanisms: Thymidine stimulates the gut microbiota to convert 5-FU prodrug (5-fluoro 2'deoxyuridine) to the toxic form 5-fluorouridine-5'-monophosphate (FUMP), which leads to toxic autophagy activation and depletes mitochondrial DNA and RNA. Serine, on the other hand, modifies E-coli 1C-metabolism, leading to DNA toxicity and host death.

Browse Drug-Microbiome Relationship