| 104 | |
| Summary | Gut microbes (species: Escherichia coli) increase 5-Fluorouracil's toxicity. |
| Gut | |
| 5-Fluorouracil (PubChem CID: 3385) | |
| Escherichia coli (Tax ID: 562) | |
| 32444616 | |
| increase toxicity | |
| A diet containing thymidine and serine could increase the toxicity of the chemotherapeutic agent, 5-Fluorouracil(5FU), via two different mechanisms: Thymidine stimulates the gut microbiota to convert 5-FU prodrug (5-fluoro 2'deoxyuridine) to the toxic form 5-fluorouridine-5'-monophosphate (FUMP), which leads to toxic autophagy activation and depletes mitochondrial DNA and RNA. Serine, on the other hand, modifies E-coli 1C-metabolism, leading to DNA toxicity and host death. |
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