PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.3 (21 March 15)

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Summary Gut microbes (species: Escherichia coli) increase 5-Fluorouracil's toxicity.
Gut
5-Fluorouracil (PubChem CID: 3385)
Escherichia coli (Tax ID: 562)
32444616
increase toxicity
A diet containing thymidine and serine could increase the chemotherapy 5-Fluorouracil(5FU) toxicity via two different mechanisms, Thymidine enhances gut microbiota to convert 5-FU prodrug (5-fluoro 2'deoxyuridine) to the toxic form 5-fluorouridine-5'-monophosphate (FUMP) which lead to toxic autophagy activation and deplete mitochondrial DNA and RNA. While serine changes E-coli 1C-metabolism leading to DNA toxicity and host death.

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