| 105 | |
| Summary | Gut microbes (genus: Lactobacillus) decrease Irinotecan's toxicity. |
| Gut | |
| Irinotecan (PubChem CID: 60838) | |
| Lactobacillus (Tax ID: 1578) | |
| 33298215 | |
| decrease toxicity | |
| Irinotecan is a chemotherapeutic agent that could be stopped because of its major side effect (mucositis). The gut microbiota may play a beneficial role in lowering irinotecan toxicity. High fiber diets increase the level of Lactobacillus and Bifidobacterium, which successfully decreased mucositis symptoms, while a low fiber diet worsened mucositis by increasing the level of Enterobacteriaceae. |
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