PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.5 (21 Mar 2021): Spring of Hope! (Release History)

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Summary Gut microbes (genus: Lactobacillus) decrease Irinotecan's toxicity.
Irinotecan (PubChem CID: 60838)
Lactobacillus (Tax ID: 1578)
decrease toxicity
Irinotecan is a chemotherapeutic agent that could be stopped because of its major side effect (mucositis). The gut microbiota may play a beneficial role in lowering irinotecan toxicity. High fiber diets increase the level of Lactobacillus and Bifidobacterium, which successfully decreased mucositis symptoms, while a low fiber diet worsened mucositis by increasing the level of Enterobacteriaceae.

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