PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.3 (21 March 15)

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Summary Gut microbes (genus: Lactobacillus) decrease Irinotecan's toxicity.
Gut
Irinotecan (PubChem CID: 60838)
Lactobacillus (Tax ID: 1578)
33298215
decrease toxicity
Irinotecan is one of the chemotherapy that could be stopped due to its side effect mucositis. Gut microbiota plays a beneficial role in lowering the severity of gut toxicity. High levels of Lactobacillus and Bifidobacterium have a protective effect on the gut as they short-chain fatty acid producers.

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