PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

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Summary Gut microbes (currently unknown members) decrease Amlodipine's activity.
Gut
Amlodipine (PubChem CID: 2162)
unknown
29391236
decrease activity
Amlodipine is an anti-hypertensive drug. Bacterial hepatic enzyme can metabolite this drug to inactive form. Dehydrogenation of the dihydropyridine moiety produces pyridine metabolite (inactive) which is a major drug metabolite.

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