PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.5 (21 Mar 2021): Spring of Hope! (Release History)

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Summary Gut microbes (genus: Bacteroides) increase 5-Fluorouracil's toxicity.
5-Fluorouracil (PubChem CID: 3385)
Bacteroides (Tax ID: 816)
increase toxicity
A toxic interaction has been reported in 18 Japanese people upon concomitant administration of sorivudine orally and 5-fluorouracil (5-FU). Bacteroides species are responsible for this toxicity owing to their production of (E)-5-(2-bromovinyl) uracil (BVU) metabolite, which in turn deactivates dihydropyrimidine dehydrogenase (DPD) responsible for the metabolism of 5-FU (Nakayama et al, 1997).

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