| 108 | |
| Summary | Gut microbes (genus: Bacteroides) increase 5-Fluorouracil's toxicity. |
| Gut | |
| 5-Fluorouracil (PubChem CID: 3385) | |
| Bacteroides (Tax ID: 816) | |
| 9110360 | |
| increase toxicity | |
| A toxic interaction has been reported in 18 Japanese people upon concomitant administration of sorivudine orally and 5-fluorouracil (5-FU). Bacteroides species are responsible for this toxicity owing to their production of (E)-5-(2-bromovinyl) uracil (BVU) metabolite, which in turn deactivates dihydropyrimidine dehydrogenase (DPD) responsible for the metabolism of 5-FU (Nakayama et al, 1997). |
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