| 109 | |
| Summary | Gut microbes (genus: Bacteroides) decrease Methotrexate's activity. |
| Gut | |
| Methotrexate (PubChem CID: 126941) | |
| Bacteroides (Tax ID: 816) | |
| 24192039 | |
| decrease activity | |
| The dihydrofolate reductase (DHF) inhibitor, methotrexate, is widely used to treat rheumatoid arthritis. Methotrexate resistance in some patients may be due to the high abundance of Bacteroides in the gut microbiota. Metagenomic analysis of the gut microbiota suggested abundance of DHF reductase-encoding genes, with an expected abundance of DHF reductase enzymes, which compete with methotrexate binding site and metabolism. |
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