PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.5 (21 Mar 2021): Spring of Hope! (Release History)

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Summary Gut microbes (genus: Bacteroides) decrease Methotrexate's activity.
Methotrexate (PubChem CID: 126941)
Bacteroides (Tax ID: 816)
decrease activity
The dihydrofolate reductase (DHF) inhibitor, methotrexate, is widely used to treat rheumatoid arthritis. Methotrexate resistance in some patients may be due to the high abundance of Bacteroides in the gut microbiota. Metagenomic analysis of the gut microbiota suggested abundance of DHF reductase-encoding genes, with an expected abundance of DHF reductase enzymes, which compete with methotrexate binding site and metabolism.

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