| 111 | |
| Summary | Gut microbes (superkingdom: Bacteria) increase Atorvastatin's activity. |
| Gut | |
| Atorvastatin (PubChem CID: 60823) | |
| Bacteria (Tax ID: 2) | |
| 32466086 | |
| increase activity | |
| Atorvastatin shows unexplained interindividual variability in lowering blood cholesterol levels in humans. In an experiment, conventional mice and antibiotic-treated mice, put on standard chow diet (SCD) or high-fat diet (HFD), were treated with atorvastatin. Results show - Minimal effect of atorvastatin in antibiotic-treated mice, compared to conventional mice - Dysbiosis resulting high Firmicutes and low Bacteroidetes in mice fed with high-fat-diet, which was partially reserved after atorvastatin treatment - Clostridium coccoides were more abundant in the high-fat diet group, and returned to normal or even above normal after atorvastatin. - The expression of hepatic and intestinal genes responsible for cholesterol metabolism, including Ldlr, Srebp2, and Npc1l1, was lowered in the gut microbiota-depleted mice. |
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