PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.5 (21 Mar 2021): Spring of Hope! (Release History)

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Summary Gut microbes (species: Ruminococcus bromii) affect Berberine's activity.
Berberine (PubChem CID: 2353)
Ruminococcus bromii (Tax ID: 40518)
affect activity
Depletion of Ruminococcus bromii with berberine, a traditional medicine used in China for many metabolic disorders, causes significant glucose levels control. Ruminococcus bromii is known to ferment dietary carbohydrates to produce single sugars. Ex vivo cultivation of Ruminococcus bromii showed inhibition in growth at Berberine concentration 25 μg/ml, thus affecting deoxycholic acid transformation ability.

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