PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.5 (21 Mar 2021): Spring of Hope! (Release History)

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Summary Gut microbes (species: Akkermansia muciniphila) increase Berberine's activity.
Berberine (PubChem CID: 2353)
Akkermansia muciniphila (Tax ID: 239935)
increase activity
Berberine an alkaloid used in China to treat several metabolic disorders. Berberine and the prebiotic stachyose are used to treat type 2 diabetes. These together show better glycemic control through modulating the gut microbiota. In mice, an increased abundance of Akkermansia muciniphila by 91.4% was observed when both drugs were combined.

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