PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.5 (21 Mar 2021): Spring of Hope! (Release History)

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Summary Gut microbes (currently unknown members) increase curcumin's activity.
Gut
curcumin (PubChem CID: 969516)
unknown
32095862
increase activity
The gut microbiota metabolizes curcumin to compounds that have neuroprotective activity. There is a bidirectional interaction between curcumin and the microbiota: - Curcumin significantly alters the abundance of members of the families Bacteroidaceae, Prevotellaceae (more specifically genera Prevotella, Bacteroides). - The gut microbiota were shown to metabolize curcumin to compounds that could be used against Alzheimer's diseases.

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