PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.5 (21 Mar 2021): Spring of Hope! (Release History)

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Summary Gut microbes (currently unknown members) decrease Oxaliplatin's toxicity.
Oxaliplatin (PubChem CID: 43805)
decrease toxicity
Hydrogenated water-induced changes in the gut microbiota significantly improve mechanical hyperalgesia caused by oxaliplatin. Oxaliplatin, a chemotherapeutic agent, can cause severe pain by mechanical hyperalgesia. Mice treated with hydrogen-rich water showed significant changes in the richness and α-diversity of the gut microbiota. High abundance of Firmicutes and Tenericutes and low abundance of Bacteroidetes were observed. The expression of TNF-α and IL-6 (P<0.05) was reduced with hydrogen-rich water treatment. Such change in expression is believed to improve chemotherapy-induced neuropathic pain.

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