| 115 | |
| Summary | Gut microbes (currently unknown members) decrease Oxaliplatin's toxicity. |
| Gut | |
| Oxaliplatin (PubChem CID: 43805) | |
| unknown | |
| 33732014 | |
| decrease toxicity | |
| Hydrogenated water-induced changes in the gut microbiota significantly improve mechanical hyperalgesia caused by oxaliplatin. Oxaliplatin, a chemotherapeutic agent, can cause severe pain by mechanical hyperalgesia. Mice treated with hydrogen-rich water showed significant changes in the richness and α-diversity of the gut microbiota. High abundance of Firmicutes and Tenericutes and low abundance of Bacteroidetes were observed. The expression of TNF-α and IL-6 (P<0.05) was reduced with hydrogen-rich water treatment. Such change in expression is believed to improve chemotherapy-induced neuropathic pain. |
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