| 116 | |
| Summary | Gut microbes (genus: Alistipes) decrease Olanzapine's bioavailability. |
| Gut | |
| Olanzapine (PubChem CID: 135398745) | |
| Alistipes (Tax ID: 239759) | |
| 33819741 | |
| decrease bioavailability | |
| Olanzapine, an orally active antipsychotic drug, was found to be more bioavailable in antibiotic-treated rats. In this study, the gut microbiota of male Sprague Dawley rats were depleted with antibiotics. Olanzapine bioavailability significantly increased (1.8-fold) in antibiotics-treated rats. It is a non-direct effect as no alteration of the ex-vivo metabolism of olanzapine. this effect is thought to be through downregulation of UGT1A3 in the duodenum after antibiotics treatment. A significant negative correlation was detected between the abundance of Alistipes and Olanzapine. |
Browse Drug-Microbiome Relationship
Home