PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.5 (21 Mar 2021): Spring of Hope! (Release History)

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Summary Gut microbes (superkingdom: Bacteria) increase Olanzapine's N/A.
Olanzapine (PubChem CID: 135398745)
Bacteria (Tax ID: 2)
increase N/A
Olanzapine is an antipsychotic drug causes weight gain side effect in patients. This study shows accelerated weight gain in olanzapine-high fat diet wild-type mice compared to olanzapine-high fat germ-free mice. Dysbiosis caused by olanzapine can be responsible for this side effect. High abundance of Firmicutes and Proteobacteria while low abundance of Bacteroidetes were observed after olanzapine treatment. Olanzapine -invitro- has antimicrobial activity inhibiting Escherichia coli growth and delaying in Enterococcus faecalis reaching log phase.

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