| 118 | |
| Summary | Gut microbes (superkingdom: Bacteria) increase Olanzapine's N/A. |
| Gut | |
| Olanzapine (PubChem CID: 135398745) | |
| Bacteria (Tax ID: 2) | |
| 25506936 | |
| increase N/A | |
| Olanzapine is an antipsychotic drug causes weight gain side effect in patients. This study shows accelerated weight gain in olanzapine-high fat diet wild-type mice compared to olanzapine-high fat germ-free mice. Dysbiosis caused by olanzapine can be responsible for this side effect. High abundance of Firmicutes and Proteobacteria while low abundance of Bacteroidetes were observed after olanzapine treatment. Olanzapine -invitro- has antimicrobial activity inhibiting Escherichia coli growth and delaying in Enterococcus faecalis reaching log phase. |
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