PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

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Summary Gut microbes (species: Fusobacterium nucleatum) affect Aspirin's toxicity.
Aspirin (PubChem CID: 2244)
Fusobacterium nucleatum (Tax ID: 851)
affect toxicity
The anti-inflammatory drug, aspirin, can be used as a chemoprotective agent against colorectal adenoma and cancer indirectly by affecting the growth and genetic expression of oncomicrobe-Fusobacterium nucleatum. Fusobacterium nucleatum is known to influence cell proliferation and immune response leading to poor prognosis and recurrence in colorectal cancer patients. In culture, aspirin could kill actively growing and stationary F.nucleatum it also can alter gene expression at low levels. In vivo, by using intestinal tumor model, ApcMin/+ mouse, the study revealed that daily aspirin is sufficient to inhibit tumor-induced by F.nucleatum. furthermore, isolates from human colorectal cancer tissues show subjects who take daily aspirin have a lower abundance of F.nucleatum by quantitative PCR on adenoma DNA.

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