| 122 | |
| Summary | Gut microbes (superkingdom: Bacteria) increase Lopinavir's toxicity. |
| Gut | |
| Lopinavir (PubChem CID: 92727) | |
| Bacteria (Tax ID: 2) | |
| 33964992 | |
| increase toxicity | |
| Possibilities of interaction between traditional herbs and antiviral drugs that used to treat Covid when used in combinations. Traditional Chinese herbs that contain glycoside need to be hydrolyzed by glycosidase in the gut microbiota to more bioavailable and pharmacologically active aglycone like: Polydatin -- B-glucosidase ----> Resveratrol Geniposide -- B-glucosidase ----> Genipin Quercetrin -- α-rhamnosidase--->Quercetin Glycyrrhizin-- B-glucuronidase--> Glycyrrhetinic acid Antiviral drugs (lopinavir, ritonavir, chloroquine, darunavir, ribavirin, arbidol, favipiravir, oseltamivir) could change microbiota composition and its enzyme thereby, inhibiting Chinese medicine activation and leading to toxic product accumulation. Results between 1 to 4 hours of lopinavir taking aglycon part of negative control as 100% to normalize the concentration: Lopinavir reduces resveratrol significantly P<0.05. Lopinavir reduces genipin significantly P<0.05. No significant reduction in quercetin. Lopinavir slightly activates glycyrrhetinic acid. |
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