PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.5 (21 Mar 2021): Spring of Hope! (Release History)

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Summary Gut microbes (superkingdom: Bacteria) increase Morphine's activity.
Morphine (PubChem CID: 5288826)
Bacteria (Tax ID: 2)
increase activity
Morphine is an opioid drug with highly addictive properties. Isorhynchophylline is a traditional Chinese medicine that is commonly used to reverse alpha and beta diversity caused by morphine. Its thought that the microbiota-gut-brain axis plays an important role in this action so in this study they try to disturb the microbiota compositions with antibiotics. it was found that the ameliorative effects of isorhynchophylline on morphine addiction were lost.

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