| 131 | |
| Summary | Gut microbes (currently unknown members) decrease Methotrexate's activity. |
| Gut | |
| Methotrexate (PubChem CID: 126941) | |
| unknown | |
| 5014749 | |
| decrease activity | |
| A dihydrofolate reductase inhibitor, methotrexate, is widely used in leukemia and many types of cancer. After intraperitoneal administration of tritiumlabeled methotrexate (3 mg/kg), a less toxic less active metabolite was found 4-amino-4-deoxy-N10-methylpteroic acid (APA). This study suggests extensive metabolite of methotrexate by CDF1 mice gut microbiota to its metabolite 4-amino-4-deoxy-N10-methylpteroic acid (APA) happened. |
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