| 132 | |
| Summary | Gut microbes (phylum: Firmicutes) decrease Methotrexate's toxicity. |
| Gut | |
| Methotrexate (PubChem CID: 126941) | |
| Firmicutes (Tax ID: 1239) | |
| 32544340 | |
| decrease toxicity | |
| Methotrexate, a chemotherapeutic agent, inhibits DNA synthesis by inhibiting folate synthesis. The gut microbiota enzyme carboxypeptidase glutamate 2 metabolizes Methotrexate to 2,4-diamino-N-10-methylpteroic acid (DAMPA). In this research, it was found that the concentration of DAMPA in feces and urine is directly proportional to firmicutes abundance in the gut. Microbiota profiling (16S rRNA gene amplicon sequencing) of fecal samples showed an increase in the relative abundance of Firmicutes over the Bacteroidetes at low doses of MTX but the reverse at high doses. |
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