| 133 | |
| Summary | Gut microbes (species: Bacteroides fragilis) decrease Methotrexate's toxicity. |
| Gut | |
| Methotrexate (PubChem CID: 126941) | |
| Bacteroides fragilis (Tax ID: 817) | |
| 30049384 | |
| decrease toxicity | |
| Methotrexate, a widely used anticancer drug, can lead to mucositis as a very common side effect. Bacteroides fragilis limits methotrexate side effect. It was observed that B. fragilis significantly decreased in methotrexate-treated mice with the increasing number of macrophages. Colonized mice gut with B. fragilis before methotrexate treatment significantly relieves gut mucositis. |
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