PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.5 (21 Mar 2021): Spring of Hope! (Release History)

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Summary Gut microbes (species: Bacteroides fragilis) decrease Methotrexate's toxicity.
Methotrexate (PubChem CID: 126941)
Bacteroides fragilis (Tax ID: 817)
decrease toxicity
Methotrexate, a widely used anticancer drug, can lead to mucositis as a very common side effect. Bacteroides fragilis limits methotrexate side effect. It was observed that B. fragilis significantly decreased in methotrexate-treated mice with the increasing number of macrophages. Colonized mice gut with B. fragilis before methotrexate treatment significantly relieves gut mucositis.

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