PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.5 (21 Mar 2021): Spring of Hope! (Release History)

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Summary Gut microbes (species: Bacteroides fragilis) increase warfarin's toxicity.
warfarin (PubChem CID: 54678486)
Bacteroides fragilis (Tax ID: 817)
increase toxicity
Warfarin is an anti-coagulant drug can be used to treat various type of thrombosis and embolism. The action of warfarin is greatly affected by antibiotics. The use of antibiotics, like fluoroquinolone or B-lactam, which could inhibit Bacteroides fragilis with warfarin leads to increase bleeding risk. This observation suggests B. fragilis have a role in warfarin action.

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