| 135 | |
| Summary | Gut microbes (currently unknown members) affect Methotrexate's activity. |
| Gut | |
| Methotrexate (PubChem CID: 126941) | |
| unknown | |
| 33314800 | |
| affect activity | |
| Methotrexate is a chemotherapeutic agent widely used to treat autoimmune diseases and malignancies. The modulation of methotrexate by the gut microbiome can vary widely between individuals. This study performed metabolomics and an Ex-vivo experiment by collecting fecal samples from responders and non-responders to MTX. Two results were found: a) MTX metabolites are differing between responder and non-responder. b)Microbiome varies between the 2 groups. |
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