PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.5 (21 Mar 2021): Spring of Hope! (Release History)

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Summary Gut microbes (currently unknown members) affect Methotrexate's activity.
Methotrexate (PubChem CID: 126941)
affect activity
Methotrexate is a chemotherapeutic agent widely used to treat autoimmune diseases and malignancies. The modulation of methotrexate by the gut microbiome can vary widely between individuals. This study performed metabolomics and an Ex-vivo experiment by collecting fecal samples from responders and non-responders to MTX. Two results were found: a) MTX metabolites are differing between responder and non-responder. b)Microbiome varies between the 2 groups.

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