PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.5 (21 Mar 2021): Spring of Hope! (Release History)

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Summary Gut microbes (species: Blautia coccoides) decrease Methotrexate's toxicity.
Methotrexate (PubChem CID: 126941)
Blautia coccoides (Tax ID: 1532)
decrease toxicity
Methotrexate is an anticancer drug can cause mucositis. It was found that co-administration with vitamins B2 and C reduces the severity of inflammation. This action was contributed to the modulation of the gut microbiome. Both of the vitamins can enhance the growth of anaerobic bacteria Blautia coccoides and Roseburia intestinalis in vitro. While administration of vitamin C in vivo reduces clinical symptoms of mucositis

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