PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.5 (21 Mar 2021): Spring of Hope! (Release History)

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Summary Gut microbes (species: Eggerthella lenta) decrease Levodopa's bioavailability.
Levodopa (PubChem CID: 6047)
Eggerthella lenta (Tax ID: 84112)
decrease bioavailability
Levodopa, antiparkinson's drug, needs to be activated to dopamine after crossing the blood-brain barrier peripheral conversion to dopamine results in many side effects. The gut microbiota mainly Enterococcus faecalis can metabolize levodopa peripherally. Enterococcus faecalis metabolizes levodopa by a pyridoxal phosphate-dependent tyrosine decarboxylase to dopamine. further conversion of dopamine to m-tyramine by Eggerthella lenta.

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