PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.5 (21 Mar 2021): Spring of Hope! (Release History)

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Summary Gut microbes (genus: Clostridium) increase olsalazine's activity.
olsalazine (PubChem CID: 22419)
Clostridium (Tax ID: 1485)
increase activity
Azo bounded is a group of antibiotics (mesalazine-sulfasalazine, balsalazide, and olsalazine) mainly used to treat ulcerative colitis. Azo bounded are prodrugs relying mainly on the human colonic microbiome in its activation. Azoreductase is an enzyme found mainly in the anaerobic bacteria responsible for azo-bounded activation. this enzyme is more predominant in the genus clostridium.

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