| 143 | |
| Summary | Gut microbes (species: Bifidobacterium pseudolongum) increase Anti- CTLA4's activity. |
| Gut | |
| Anti- CTLA4 (PubChem CID: 123) | |
| Bifidobacterium pseudolongum (Tax ID: 1694) | |
| 32792462 | |
| increase activity | |
| Immune checkpoint inhibitors (ICI) are an effective treatment in many types of cancer that enhance cytotoxic T cells killing activities against cancer cells. Inosine, a metabolite, secreted by the presence of Bifidobacterium pseudolongum in the intestine. ICI increases intestine permeability to inosine which augments its action as it has the ability to activate T cells through adenosine A2a receptors. therefore, the presence of Bifidobacterium pseudolongum can enhance ICI activity. |
Browse Drug-Microbiome Relationship
Home