PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.5 (21 Mar 2021): Spring of Hope! (Release History)

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Summary Gut microbes (genus: Akkermansia) increase Berberine's activity.
Berberine (PubChem CID: 2353)
Akkermansia (Tax ID: 239934)
increase activity
Berberine, a drug used to treat type 2 diabetes, has a better effect when combined with stachyose. Berberine and stachyose together show reduce glucose levels and better tolerance compared to berberine alone in rats. The aim of this study is to understand the difference between berberine and berberine with stachyose. The analysis of the gut microbiota profile shows a decrease in the abundance of pathogenic Enterobacteriaceae, Desulfovibrionaceae, and Proteobacteria while the abundance of the beneficial Akkermansiaceae was increased in comparison to berberine alone. The modulation of the gut microbiota by the two drugs could explain this effect.

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