PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.5 (21 Mar 2021): Spring of Hope! (Release History)

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Summary Gut microbes (currently unknown members) affect Methotrexate's activity.
Methotrexate (PubChem CID: 126941)
affect activity
Methotrexate, a dihydrofolate reductase inhibitor, is used to treat rheumatoid arthritis. Methotrexate affects the dihydrofolate of both mammalian and bacterial cells. So the gut microbiota of the patient will vary between the treated and non-treated groups. surprisingly, responders and non-responders also differ in their gut microbiome suggesting the role of microbiota in drug action. Fecal transplantation to germ-free mice of responder shows reduced immune activation post induced inflammation compared to non-responder and control groups that could augment the role of microbiota in methotrexate treatment.

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