PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.5 (21 Mar 2021): Spring of Hope! (Release History)

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Summary Gut microbes (species: Lactobacillus reuteri) decrease Rituximab's toxicity.
Rituximab (PubChem CID: 46488338)
Lactobacillus reuteri (Tax ID: 1598)
decrease toxicity
An immune therapy, Rituximab, is widely used to treat cancer. It is associated with gut problems like mucositis. It is approved that dysbiosis of the gut microbiota has a link with the cause of mucositis. Rituximab reduces the abundance of Lactobacillus reuteri in the gut. The oral administration of Lactobacillus reuteri controls the inflammatory process caused by rituximab by regulating the T helper cells' level.

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