| 149 | |
| Summary | Gut microbes (phylum: Firmicutes) increase sulfanilamide's bioavailability. |
| Gut | |
| sulfanilamide (PubChem CID: 5333) | |
| Firmicutes (Tax ID: 1239) | |
| 34625106 | |
| increase bioavailability | |
| Sulfanilamide is an antibiotic prodrug that needs to be activated by the azo-reductase enzymes by the gut microbiota. In vitro experiment, incubating stools sample suspension directly with sulfanilamide shows that the high abundance of firmicutes in stool samples correlated with high azo-reducing activity, unlike Bacteroides which correlated with a low level of azoreductase activity. |
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