PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.5 (21 Mar 2021): Spring of Hope! (Release History)

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Summary Gut microbes (currently unknown members) increase Metronidazole's metabolic processing.
Metronidazole (PubChem CID: 4173)
increase metabolic processing
Metronidazole, nitroimidazole antimicrobials, is used to kill bacteria and parasites by interacting with DNA and causing a loss of its helical structure. The gut microbiome indirectly interferes with metronidazole metabolism by inhibiting certain types of cytochromes (CYP450). A higher level of plasma concentration of metronidazole was observed in germ-free mice. An inhibition of enzymatic activity of CYP2A and CYP3A was reported in germ free mice which affect the drug metabolism.

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