| 154 | |
| Summary | Gut microbes (currently unknown members) increase Metronidazole's metabolic processing. |
| Gut | |
| Metronidazole (PubChem CID: 4173) | |
| unknown | |
| 34752478 | |
| increase metabolic processing | |
| Metronidazole, nitroimidazole antimicrobials, is used to kill bacteria and parasites by interacting with DNA and causing a loss of its helical structure. The gut microbiome indirectly interferes with metronidazole metabolism by inhibiting certain types of cytochromes (CYP450). A higher level of plasma concentration of metronidazole was observed in germ-free mice. An inhibition of enzymatic activity of CYP2A and CYP3A was reported in germ free mice which affect the drug metabolism. |
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