| 156 | |
| Summary | Gut microbes (superkingdom: Bacteria) increase Irinotecan's toxicity. |
| Gut | |
| Irinotecan (PubChem CID: 60838) | |
| Bacteria (Tax ID: 2) | |
| 36864380 | |
| increase toxicity | |
| The microbiota increases irinotecan toxicity through expression of bacterial β-glucuronidase. In this mouse model, irinotecan treatment caused an increase in Veillonella, Clostridium, Butryicicoccus, and Prevotella. Using Lactobacillus spp. mixture as probiotic (in the same mouse model) significantly alleviated irinotecan-induced diarrhea through the reduction of both β-glucuronidase expression and reactive oxygen species (ROS). The use of probiotics in this model also protected the gut epithelium from proliferative crypt injury. |
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