PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.5 (21 Mar 2021): Spring of Hope! (Release History)

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Summary Gut microbes (currently unknown members) affect eltrombopag 's cleavage.
eltrombopag (PubChem CID: 135449332)
affect cleavage
Human gut microbes are able to cleave the hydrazine linkage of orally administered eltrombopag, used to treat low blood platelet counts sometimes, into its metabolites. These metabolites are exclusively eliminated in urine. In mice and in vitro, antibiotic treatment inhibited eltrombopag cleavage. These results were demonstrated upon anaerobic incubation with rodent cecal contents or human fecal homogenate.

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