PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.3 (21 March 15)

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Summary Gut microbes (currently unknown members) affect eltrombopag 's cleavage.
Gut
eltrombopag (PubChem CID: 25181561)
unknown
21646438
affect cleavage
Human gut microbes are able to cleave the hydrazine linkage of orally administered eltrombopag to metabolites. These metabolites are exclusively eliminated in urine. In mice, antibiotic treatment inhibited eltrombopag cleavage.

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