PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.5 (21 Mar 2021): Spring of Hope! (Release History)

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Summary Gut microbes (species: Eggerthella lenta) decrease digoxin's toxicity.
digoxin (PubChem CID: 2724385)
Eggerthella lenta (Tax ID: 84112)
decrease toxicity
Altered concentration of Eubacterium lentum (now Eggerthella lenta) between populations has been correlated with the difference in reduced digoxin metabolite concentration (digoxin reduction products). Comparing reduced digoxin metabolite profiles between North Americans and Southern Indians indicated that 36% of the former and 13.7% of the latter were capable of reducing digoxin. This discrepancy has been correlated with altered concentrations of E. lentum between the two populations (Mathan et al, 1989). Furthermore, a case-control study showed that concomitant administration of digoxin and erythromycin or tetracycline resulted in digoxin intoxication. Accordingly, it was recommended to avoid the concurrent use of both medications. The authors of the study proposed the reduction in E. lentum among the potential underlying causes for this toxicity (Lindenbaum et al, 1981).

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