PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.3 (21 March 15)

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Summary Gut microbes (species: Eggerthella lenta) decrease digoxin's toxicity.
digoxin (PubChem CID: 2724385)
Eggerthella lenta (Tax ID: 84112)
decrease toxicity
Altered concentration of E. lentum between populations has been correlated with the difference in the reduced metabolite concentration. Comparing the reduced digoxin metabolite profiles between North Americans and Southern Indians showed 36% and 13.7% respectively which has been correlated with altered concentrations of E. lentum between the two populations (Mathan et al, 1989). Furthermore, a recent case-control study, has showed that concomitant administration of digoxin and erythromycin or tetracycline has resulted in digoxin intoxication. Accordingly, it is recommended to avoid the concurrent use of both medications. The authors of the study proposed the reduction in E. lentum among the potential underlying causes for this toxicity (Lindenbaum et al, 1981).

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