PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.3 (21 March 15)

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Summary Gut microbes (currently unknown members) affect phosphatidylcholine's metabolic processing.
Gut
phosphatidylcholine (PubChem CID: 452110)
unknown
21475195
affect metabolic processing
Gut microbiota-dependent metabolism of dietary phosphatidylcholine is believed to increase cardiovascular disease (CVD) pathogenesis. Three metabolites of the dietary lipid phosphatidylcholine: choline, trimethylamine N-oxide (TMAO), and betaine were shown to predict risk for CVD. Suppression of intestinal microbiota in atherosclerosis-prone mice inhibited dietary-choline-enhanced atherosclerosis.

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