PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.5 (21 Mar 2021): Spring of Hope! (Release History)

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Summary Gut microbes (species: Bifidobacterium bifidum) affect gliadin's N/A.
gliadin (PubChem CID: 17787981)
Bifidobacterium bifidum (Tax ID: 1681)
affect N/A
Fragments of the dietary wheat gluten proteins (gliadins) alone or together with the proinflammatory cytokine interferon significantly decreased the number of goblet cells in the small intestine. This effect was more pronounced in the presence of Escherichia coli and Shigella. The number of goblet cells in the small intestine increased by the simultaneous incubation of Bifidobacterium bifidum with gliadin. These results suggest that the composition of the intestinal microbiota affects the permeability of the intestinal mucosa and, consequently, could be involved in the early stages of celiac disease pathogenesis.

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