PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.3 (21 March 15)

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Summary Gut microbes (currently unknown members) affect urolithin-A's response to substance.
Gut
urolithin-A (PubChem CID: 5488186)
unknown
19616930
affect response to substance
Studies in rats showed that pomegranate extract (PE) and its main microbiota-derived metabolite urolithin-A (UROA) favorably modulate the gut microbiota. In healthy subjects, UROA could be the most active anti-inflammatory compound derived from pomegranate ingestion; however, in colon inflammation, the effects are likely due to the nonmetabolized ellagitannin-related fraction of PE.

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