PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.3 (21 March 15)

Detailed View

25
Summary Gut microbes (currently unknown members) are affected by Splenda's N/A.
Gut
Splenda (PubChem CID: 71485)
unknown
18800291
are affected by N/A
Evidence indicates that administration of Splenda exerted numerous adverse effects, including reduction in beneficial fecal microflora...> the numbers of total anaerobes (bifidobacteria, lactobacilli, Bacteroides, clostridia), and total aerobic bacteria were significantly decreased, increased fecal pH, and enhanced expression levels of P-glycoprotien, CYP3A4, and CYP2D1, which are known to limit the bioavailability of orally administered drugs.

Browse Drug-Microbiome Relationship
Home