PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.3 (21 March 15)

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Summary Gut microbes (currently unknown members) N/A indomethacin's N/A.
Gut
indomethacin (PubChem CID: 3715)
unknown
15979923
N/A N/A
Oral administration of indomethacin produces oxidative damage in the small intestine and attenuation of the glycocalyx layer of the mucosa. Alterations in glycosylation of SLP and BBM in response to indomethacin, along with qualitative and quantitative changes in the luminal bacterial flora, may facilitate translocation of bacteria into the mucosa. These changes may contribute to the enteropathy observed as a result of NSAID treatment.

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