| 38 | |
| Summary | Gut microbes (currently unknown members) affect Z-300's reduction. |
| Gut | |
| Z-300 (PubChem CID: 124488) | |
| unknown | |
| 10553721 | |
| affect reduction | |
| The metabolisms of the histamine H2-receptor antagonist, Z-300*, in rats was found to produce five metabolites, namely sulfoxide (SO), sulfone (SO2), phenol (PH), propionic acid (PA) and thioglycolic acid (TH) derivatives. Experimental results suggested that the SO metabolite could reduced to Z-300 by the gut microbiota in the lower intestine. *Z-300 = N-(3-(3-(piperidinomethyl)phenoxy)-propyl)-2-(2-hydroxyethyl-1-thio)acetamido.2-(4-hydroxybenzoyl)benzoate |
Browse Drug-Microbiome Relationship
Home