PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.3 (21 March 15)

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Summary Gut microbes (currently unknown members) affect Z-300's reduction.
Gut
Z-300 (PubChem CID: 124488)
unknown
10553721
affect reduction
The metabolisms of Z-300 in rat was found to produce five metabolites, namely as sulphoxide (SO), sulphone (SO2), phenol (PH), propionic acid (PA) and thioglycolic acid (TH) derivatives. The results suggest that SO was reduced to Z-300 by gut flora in the lower intestine.

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