PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.3 (21 March 15)

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Summary Gut microbes (currently unknown members) affect acetaminophen's O-sulfonation.
Gut
acetaminophen (PubChem CID: 1983)
unknown
19667173
affect O-sulfonation
Acetaminophen toxicity is associated with elevated levels of p-cresol which is produced by some bacterial community owing to the competition of p-cresol with acetaminophen on the o-sulfonation metabolism. Thereby, it has been suggested to establish the assessment of microbiome activity as a guideline prior to the administration of acetamniophen.

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