PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.5 (21 Mar 2021): Spring of Hope! (Release History)

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Summary Gut microbes (currently unknown members) affect cycloheximide 's toxicity.
cycloheximide (PubChem CID: 6197)
affect toxicity
The three drugs dexamethasone, promethazine and nordihydroguaiaretic acid were observed to sensitize mice to an otherwise-tolerated dose of cycloheximide. It was suggested that the three agents induced fatal susceptibility to cycloheximide through the action of the gut microbiota. It was also proposed that the three drugs impair the hepatic mechanism which removes endogenous lipopolysaccharide from the portal vein. The resulting systemic distribution of lipopolysaccharide was described before to render mice fatally susceptible to subsequent cycloheximide challenge.

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