PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.5 (21 Mar 2021): Spring of Hope! (Release History)

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Summary Gut microbes (currently unknown members) affect Loperamide oxide's reduction.
Loperamide oxide (PubChem CID: 71421)
affect reduction
The intestinal microbiota is able to reduce the prodrug, loperamide oxide (LOPOX), to loperamide (LOP) under anaerobic conditions. Different experiments in dogs, rats, and using human ileal effluents confirmed this observation. In germ-free rats), LOPOX reduction could still be conducted by unknown components of the gut contents. LOP is uptaken 3-10 times faster than LOPOX in isolated intestinal cells.

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