| 42 | |
| Summary | Gut microbes (currently unknown members) affect Loperamide oxide's reduction. |
| Gut | |
| Loperamide oxide (PubChem CID: 71421) | |
| unknown | |
| 7628301 | |
| affect reduction | |
| The intestinal microbiota is able to reduce the prodrug, loperamide oxide (LOPOX), to loperamide (LOP) under anaerobic conditions. Different experiments in dogs, rats, and using human ileal effluents confirmed this observation. In germ-free rats), LOPOX reduction could still be conducted by unknown components of the gut contents. LOP is uptaken 3-10 times faster than LOPOX in isolated intestinal cells. |
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