| 52 | |
| Summary | Gut microbes (currently unknown members) N/A Misonidazole's reduction. |
| Gut | |
| Misonidazole (PubChem CID: 104231655) | |
| unknown | |
| 6260109 | |
| N/A reduction | |
| Misonidazole, a radiation sensitizer, is metabolized to its amino derivative [1-(2-aminoimidazol-1-yl)- 3-methoxypropan-2-ol] in pure or mixed cultures of the intestinal microbiota. The metabolite is further metabolized to release CO2. This activity is backed by in vivo evidence: the metabolite was detected in the excreta of conventional but not germ-free rats. |
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